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KMID : 0615720140310040057
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Jouranl of Korean Acupuncture and Moxibustion society
2014 Volume.31 No. 4 p.57 ~ p.70
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Effects of Clematidis Radix Pharmacopuncture Injected at Sinsu (BL23) on Neuropathic Pain in Rats
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Kim Sung-Phil
Choi Sun-Mi
Kim Jung-Eun
Kim Joo-Hee
Shin Kyung-Min
Kim Jae-Hong
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Abstract
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Objectives: The purpose of this study is to examine if Clematidis Radix(CR) pharmacopuncture may be effective to the neuropathic pain(mechanical allodynia) in a rat model of neuropathic pain.
Methods: To produce the model of neuropathic, L5 spinal nerve was ligated by 6-0 silk thread. After neuropathic surgery, the author examined if the animals exhibited the plantar withdrawal response of allodynia. The plantar withdrawal response was assessed by dynamic plantar aesthesiometer three days after the neuropathic surgery, CR pharmacopuncture was injected at BL23 1time/week for 6 weeks. After that, the author examined the plantar withdrawal response of rats’ leg by dynamic plantar aesthesiometer. And also the author examined mGluR5, Bax, Bcl-2, Bax/Bcl-2 ratio in spinal cord, and c-Fos. Also the author observed the change of aspartate aminotransferase(AST), alanine aminotransferase(ALT) count in the blood serum of neuropathic rats.
Results:
1.The withdrawal response of allodynia decreased in the PT3, PT4 group as compared with control group.
2.The mGluR5 increased in the PT1, PT2, PT3, and PT4 group.
3.The Bax and Bax/Bcl-2 ratio decreased in the PT4 group.
4.The c-Fos increased in the PT1 group, and decreased in the PT4 group.
5.The changes of AST in blood serum decreased in the every group excluded control group and the changes of ALT in blood serum isn’t shown the signigicant change.
Conclusions: These results are suggested that CR pharmacopuncture at BL23 decreased mechanical allodynia, can act on anti-apoptotic, neuroprotective effects and liver fuction in the model of neuropathic pain.
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KEYWORD
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Neuropathic pain, Clematidis radix pharmacopuncture, Sinsu (BL23).
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